Christopher Rose's Personal Page
Research Interests:
My research is on the role of hormones in the development and evolution of
amphibians. I am interested specifically in their metamorphosis, which is a
dramatic change in body form that is regulated by thyroid hormone (TH) and
results in remarkable variation in skeletal anatomy.
The question of current interest is how do similar tissues in a frog skull
respond to TH in different ways. One aspect of this project is to survey the
mouth and throat skeleton of Xenopus laevis frogs at metamorphic stages to map out the patterns of cell proliferation and cell death in the different
cartilages. A second is to transplant neural crest cells between frog embryos
to form tadpoles with extra skeletal elements in new parts of the head, , e.g.
a jaw cartilage in place of a gill arch cartilage, and then monitor how these
cartilages respond to TH. A third aspect is to modify the pattern of Hox gene
expression in one cartilage to transform its larval shape and then see whether
its TH response has also been affected. The ultimate goal is to understand not
only how TH responses are specified in frog cartilages but how these responses
may be altered in evolution to produce different remodelling pathways in
different species. The research techniques range from rearing amphibian larvae
to osteological and morphometric analyses, in situ hybridization,
immunohistochemistry, tissue grafting and cell injection.
I also teach and write about the role of popular culture and movies in
biology education.
Publications
Rose, C.S. 2007. Biology in the movies: Using the double-edged sword of popular culture to enhance public understanding of science. Evol. Biol. 34: 49-54.
Wang, Y. and C.S. Rose. 2005. Jeholotriton paradoxus (Amphibian: Caudata) from the Lower Cretaceous of Southeastern Inner Mongolia, China. J. Vertebrate Paleontol. 25(3): 523-532.
Rose, C.S. 2005. Integrating ecology and developmental biology to explain the timing of frog metamorphosis. Trends in Ecology and Evolution 20: 129-135.
Rose, C.S. 2003. Thyroid hormone
mediated development in vertebrates: What makes frogs unique? In: Environment,
Development and Evolution, Toward a Synthesis, G. B. Müller, B. K.
Hall, R. D. Pearson, eds. Vienna Series in Theoretical Biology. Cambridge: MIT
Press, pp. 197-237.
Rose, C.S. 2003. The developmental morphology of salamander skulls. In:
Amphibian Biology, Vol. 5. Osteology, H.
Heatwole and M Davies, ed., Australia: Surrey Beatty and Sons Pty. Ltd., pp.
1686-1783.
Rose, C.S. 2003. How to teach biology using the movie science of cloning
people, resurrecting the dead, and combining flies and humans. Public
Understand. Sci. 12: 289-296.
Rose, C.S. 2002. The origin and evolution of metamorphosis. In: Encyclopedia
of Evolution, Vol. 2. M. Pagel, ed. Oxford:
Oxford University Press, pp. 720-724.
Rose, C.S. 1999. Hormonal control in larval development and evolution -
Amphibians. In: The Origin and Evolution of Larval Forms, B.K. Hall and M.H. Wake, eds. San Diego: Academic
Press, pp. 167-216.
Berry, D.L., C.S. Rose, B.F. Remo, and D.D. Brown. 1998. The expression pattern
of thyroid hormone response genes in remodeling tadpole tissues defines
distinct growth and resorption gene expression programs. Dev. Biol. 203: 24-35.
Rose, C.S. 1996. An endocrine-based model for developmental and morphogenetic
diversification in metamorphic and paedomorphic urodeles. J. Zool. 239: 253-84.
Rose, C.S. 1995. Skeletal morphogenesis in the urodele skull: I. Postembryonic
development in the Hemidactyliini (Amphibia: Plethodontidae). J. Morphol. 223:
125-148.
Rose, C.S. 1995. Skeletal morphogenesis in the urodele skull: II. Effect of
developmental stage in TH-induced remodelling. J. Morphol. 223: 149-166.
Rose, C.S. 1995. Skeletal morphogenesis in the urodele skull: III. Effect of
hormone dosage in TH-induced remodelling. J. Morphol. 223: 243-261.
Rose, C.S. 1995. Intraspecific variation in ceratobranchial number in
Hemidactylium scutatum (Amphibia: Plethodontidae): Developmental and systematic
implications. Copeia 1995: 228-232.
Rose, C.S. and J.O. Reiss. 1993. Metamorphosis and the vertebrate skull:
Ontogenetic patterns and developmental mechanisms. In: The Skull,
Vol. 1, Development, J. Hanken and B.K. Hall, eds. Chicago: Univ.
Chicago Press, pp. 289-346.
Sammarco, P.W., M.J. Risk and C.S. Rose. 1987. Effects of grazing and
damselfish territoriality on internal bioerosion of dead corals: indirect
effects. J. Exp. Marine Biol. Ecol., 112: 185-199.
Rose, C.S. and M.J. Risk. 1985. Increase in Cliona delitrix infestation of
Montastrea cavernosa heads on an organically polluted portion of the Grand
Cayman fringing reef. Marine Ecol. (Publ. Stn. Zool. Napoli I), 6(4): 345-363.
Nonscientific presentations
From Shelley to Crichton, The Movie Science of Resurrecting the Dead.
From Aristotle to Chuck Jones, the Popular History of Amphibians.
Undergraduate courses taught at JMU
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Graduate courses taught at JMU
BIO 630:
Metamorphosis: Ecology, Evolution and Development